SUMMARY
Background：The findings of epidemiologic studies on the association between egg consumption and ovarian cancer risk remain conflicting. The aim of this meta-analysis was to investigate whether an association exists between egg intake and ovarian cancer risk in epidemiologic studies.
Methods：A literature search was carried out using PUBMED, EMBASE, and Cochrane Library Central database for all medical literature published in English-language journals up to August 2013. Before meta- analysis, between-study heterogeneity and publication bias were assessed using adequate statistical tests. Fixed-effect and random-effect models were used to estimate summary relative risks (RR) and the corresponding 95% confidence intervals (CIs). Subgroup analyses and sensitivity analysis were also performed.
Results：A total of 12 eligible studies (six case-control studies and six cohort studies) were included, involving 629,453 subjects and 3728 ovarian cancer cases. We found that high egg intake (comparing the highest with the lowest category) was associated with a significant increased risk of ovarian cancer (RR ¼ 1.21, 95% CI [1.06, 1.38]). When we examined whether the associations differed by study type, statistically significant effect of egg intake on ovarian cancer was observed among case-control studies (RR ¼ 1.22, 95% CI [1.03, 1.43]), but not among cohort studies (RR ¼ 1.20, 95% CI [0.97, 1.48]).
Conclusions：Our findings suggest that egg consumption may increase ovarian cancer risk. Additional studies, especially large prospective cohort studies, are warranted to confirm the findings.
（塞尔维亚）《临床营养学》
【标题】鸡蛋消费与卵巢癌风险增加有关：证据来自一项观察性研究的荟萃分析
【作者】Sai-tian Zeng, Liang Guo*, Shi-kai Liu, Dong-hui Wang, Jie Xi, Ping Huang, Dan-tong Liu, Jie-fan Gao, Jing Feng, Liang Zhang
河北医科大学沧州中心医院妇科
【摘要】
1、背景：流行病学研究发现在关于鸡蛋摄入与卵巢癌风险之间的相关性上仍是矛盾的。本文这项荟萃分析的目的是调查流行病学研究中鸡蛋摄入量与卵巢癌风险之间是否存在关联。
2、方法：使用了PUBMED、EMBASE和Cochrane图书馆中央数据库，检索时间截止到2013年8月在英文期刊上发表的所有医学文献。在进行荟萃分析之前，使用了充分的统计检验来评估研究间的异质性和发表偏倚。使用了固定效应和随机效应模型评估总结相对风险(RR)和相应95%置信区间(CIs)。进行了亚组分析和敏感性分析。
3、结果：共纳入12项符合条件的研究(6项病例对照研究和6项队列研究)，涉及629453名受试者和3728例卵巢癌病例。我们发现，较高的鸡蛋摄入量(与最低类别相比)与卵巢癌风险显著增加相关(RR=1.21，95%CI[1.06，1.38])。当我们检查这些关联是否因研究类型不同而不同时，在病例对照研究中(RR=1.22，95%CI[1.03，1.43])观察到鸡蛋摄入对卵巢癌风险有统计学意义，但在队列研究中没有观察到(RR=1.20，95%CI[0.97，1.48])。
4、结论：我们的研究显示，摄入鸡蛋可能增加卵巢癌的风险。另外相关的研究，特别是大型的前瞻性队列研究，可确保证实这一发现。